MBF Bioscience BrainMaker for 3D brain reconstructions

Used in applications in neuroscience research, MBF Bioscience’s BrainMaker generates high-resolution 3D reconstructions from serial sections imaged with whole slide scanners and research microscopes.

The images are loaded into the product, which automatically detects the individual sections on each slide and then aligns the sections to create the full 3D image reconstruction of the entire brain (or any organ). At a single glance the user can see the location of all neurons expressing a particular gene, visualising axonal projections of specific neurons within the full anatomical context.

If the user mounts a section upside down, BrainMaker will automatically correct it during the alignment process. The device uses innovative computational algorithms to align image features found in multiple serial sections. If additional adjustments need to be made to the automatic alignment, researchers can easily edit the 3D reconstruction.

The product allows the user to analyse the size and shape of neurons within the 3D reconstruction using Neurolucida 360 or analyse the number of neurons or the volume of a lesion with Stereo Investigator. Reconstructions can be stored, viewed and shared with Biolucida, MBF’s platform for organising and sharing big image data.