Malvern NanoSight NS300 particle-by-particle size and concentration measurement with fluorescence detection

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Nanoparticle Tracking Analysis (NTA) uses the properties of both light scattering and Brownian motion to characterise individual nanoparticles in a liquid suspension in real time. The technique is fast, robust and accurate, representing an attractive complement to existing methods of nanoparticle analysis such as dynamic light scattering (DLS), photon correlation spectroscopy (PCS) and electron microscopy (EM).

The NanoSight NS300 from Malvern Instruments uses NTA to analyse particles in liquids from 10–2000 nm in diameter. The easy-to-use, reproducible platform delivers simultaneous measurements while visual validation of results gives the user extra confidence. As well as particle size distribution and concentration, protein aggregation and viscosity can all be analysed while a fluorescence mode provides detection of labelled particles.

Nanoparticle Tracking Analysis is a high-resolution particle sizing technique suitable for polydisperse systems. The NanoSight NS300 offers minimal sample preparation, user-friendly software with easy set-up of SOPs for routine use and the option of automated multiple sample analysis when used with a syringe pump or autosampler.

Applications include the development of drug delivery systems, viral vaccine research, nanotoxicology, protein aggregation studies, exosomes and microvesicles (extracellular vesicles) characterisation and more.

For more information: http://atascientific.com.au/nano-sight-systems.html.