Wyatt Technology has available its refractive index detector - the Optilab rEX that is claimed to have 256 times the detection power and up to 50 times the dynamic range of other RI detectors.
With a combination of semiconductor photodiode and computer algorithms, the instrument includes the ability to view the full range of detection at all times.
It can also measure the dn/dc of a solvent at the same wavelength of light as a light scattering instrument, enabling absolute molecular weight determinations.
The device can also measure the absolute refractive index of a solution and shares the ability of its predecessor to reach below ambient temperatures as easily as above ambient. The temperature control can be programmed between 4 and 50°C and is compatible with all HPLC systems.
