Genomics

Article (3)
  • To shmoo or not to shmoo?
    Yeast cells decide whether to have sex with each other within two minutes of meeting according to research published in ‘Nature’. One of the authors of the study, from Imperial College London, says the new insights into how yeast cells decide to mate could be helpful for researchers looking at how cancer cells and stem cells develop.
  • Genome bar-coding system reveals large-scale variation in human DNA
    "Our newer genome analysis systems, if commercialised, promise genome analysis in one hour, at under $1000," Schwartz says. "And we require that high speed and low cost to power the new field of personal genomics."
  • Computational feat speeds finding of genes to milliseconds instead of years
    Like a magician who says, “Pick a card, any card”, Stanford University computer scientist Debashis Sahoo, PhD, seemed to be offering some kind of trick when he asked researchers at the Stanford Institute for Stem Cell Biology and Regenerative Medicine to pick any two genes already known to be involved in stem cell development.
Feature (5)
  • First human DNA large-scale variation map is produced
    Researchers in the US have produced the first sequence-based map of large-scale structural variation across the human genome.
  • Unnatural selection
    In 2000-2001, the four-million-odd cows making the NZ dairy herd were screened for their milk composition by ViaLactia. One cow, Marge, was thoughtfully purchased for $300 when it was found that her milk was particularly low in saturated fat
  • A new concept of genes
    The FANTOM Consortium for Genome Exploration Research Group has published two milestone papers in the journal Science, which transform our understanding of the information content of the mammalian genome
  • NMR method rapidly solves genomic structures
    A University at Buffalo scientist created a stir in 2003 when he announced a much faster, more precise and far less expensive method of obtaining nuclear magnetic resonance (NMR) data to map a protein's atomic structure
  • Sex keeps your genome clean
    When sexual species reproduce asexually, they accumulate bad mutations at an increased rate, report two Indiana University evolutionary biologists. The researchers used the model species Daphnia pulex, or water flea, for their studies
Product (24)
  • Golden Helix SNP & Variation Suite 7
    As part of its genomics portfolio, Golden Helix provides an analysis suite that is compatible with most platforms, including Affymetrix.
  • SOLiD PI genetic sequencing system
    The SOLiD PI System is an accurate, flexible and easy-to-use genomic analysis platform that will bring next-generation sequencing within the grasp of all life science research laboratories.
  • Applied Biosystems 3500 Series Genetic Analyzer
    LifeTechnologies has launched a genetic analysis system designed to optimise data quality and deliver increased reliability, performance, quality assurance and ease of use specifically for forensic DNA testing laboratories.
  • GeneCopoeia expression-ready clones
    GeneCopoeia full-length expression-ready clones can be used to accelerate research and publish faster.
  • Illumina Genome AnalyzerIIe sequencing system
    The Illumina Genome AnalyzerIIe sequencing system has been designed to provide a lower-priced entry point into next-generation sequencing. The system leverages the architecture of Illumina’s Genome AnalyzerIIx and its sequencing-by-synthesis chemistry to generate approximately 200 million paired-end reads and 20 gigabases of data per run at launch. As Illumina introduces advances to increase the output of the Genome AnalyzerIIx to 95 Gb, the output of the Genome AnalyzerIIe is expected to reach 40 Gb and 300 million paired-end reads per run.
  • Applied Biosystems SOLiD 3 Plus genomic analysis platform
    Applied Biosystems’ SOLiD 3 Plus System, a genomic analysis platform, is designed for users working towards mainstream sequencing of personal genomes for clinical research and personalised medicine.
  • PerkinElmer AutomatedGSP Genetic Screening Processor
    PerkinElmer has received the first 510(k) clearance from the US Food and Drug Administration for its automated GSP Genetic Screening Processor, used by public health laboratories as part of newborn screening programs.
  • Invitrogen BenchPro 4100 automated western blot processor
    Invitrogen’s BenchPro 4100 automated western blot processor works at the push of a button. Hands-on time, clean-up and cross-contamination are eliminated while ensuring highly sensitive, reproducible detection.
  • Transfection system
    Invitrogen’s Neon Transfection System efficiently delivers nucleic acids into all mammalian cell types including primary, stem and difficult-to-transfect cells. The system is for scientists performing gene function experiments who want the flexibility of an open system which allows for customisation and optimisation of existing or user-defined protocols.
  • Cytogenetics research solution
    The next-generation Affymetrix Cytogenetics Research Solution includes arrays, reagents and analysis software for the detection of a broad range of chromosome aberrations affecting phenotypes.
  • Single-run human genome sequencing
    Applied Biosystems recently announced that its research and development scientists used human disease samples from the Baylor College of Medicine Human Genome Sequencing Center to sequence an entire human genome in a single run at 17-fold coverage using the SOLiD 3 System.
  • Next-generation sequencing service
    Foreshadowing the changes in the next-generation sequencing market, AGRF is expanding its current range of next-generation sequencing services via the acquisition of the illumina Genome Analyser II (GA II, utilising Solexa technology). The GA II service, combined with the established Roche GS FLX (454) service, will enable the genomics research community to access a suite of scalable next-generation sequencing services spanning both long and short read lengths.
  • Recombinant human albumin
    Novozymes has developed a range of recombinant human albumins (rHAs) (LONG R3IGF-I, Albufuse, CellPrime rAlbumin AF-S) suitable for industrial cell culture and biomedical applications, such as protein, drug and vaccine formulation and medical device coating.
  • Short read de novo analysis
    Applied Biosystems has expanded its suite of bioinformatics solutions to include de novo assembly of small organisms on the Solid 3 System, the company’s sequencing platform that enables the comprehensive analysis of genomes, transcriptomes and epigenomes.
  • Gene-based search tool
    Your Favorite Gene (www.sigma.com/yfg) is a comprehensive, web-based search tool that matches genes of interest against thousands of Sigma-Aldrich research products. This flexible search engine matches 150,000 shRNAs, 725,000 siRNAs, 4000 antibodies, proteins and kits, and 1000 bioactive small molecules to specific genes of interest.
  • Gene knockout vectors
    Sigma-Aldrich has introduced TargeTron vectors designed for use with the TargeTron gene knockout system. The vectors enhance the capabilities and increase the flexibility of the system providing researchers with a targeted method to knock out multiple genes in prokaryotic organisms, to generate knockouts without using selection or by using removable selection and to produce knockouts in organisms lacking a source of T7 RNA polymerase.
  • Gene knockout vectors
    Sigma-Aldrich has introduced TargeTron vectors designed for use with the TargeTron gene knockout system. The vectors enhance the capabilities and increase the flexibility of the system providing researchers with a targeted method to knock out multiple genes in prokaryotic organisms, to generate knockouts without using selection or by using removable selection and to produce knockouts in organisms lacking a source of T7 RNA polymerase.
  • Technical notes
    Scientifix has released the latest edition of Clontechniques.
  • Genetic variant identification
    Variant Reporter software is designed to accelerate the analysis of genetic variation data. The Variant Reporter Software reduces manual review time of these data by automating the detection of genetic variants and streamlining the data analysis process. Applied Biosystems expects that the software can reduce by up to half the time currently required to evaluate genetic variation data generated during medical sequencing projects.
  • Human gene array
    Affymetrix has released the GeneChip Human Gene 1.0 ST Array, the latest addition to its Whole-Transcript (WT) assay-based gene expression product family. With the Human Gene 1.0 ST Array design, each of the targeted 28,869 genes is interrogated by an average of 26 probes targeting exon content spread across the entire length of each gene.
  • Genome-wide RNAi library with cellular screening system
    Xantos Biomedicine AG and Qiagen have announced their partnership for co-marketing Qiagen's proprietary TOM-amidite chemistry-based genome-wide RNAi products with Xantos' automated cell-based screening platform, XantoScreen. By combining the capabilities of both companies' platforms users will be able to rapidly perform gene analysis and unravel the function and role of genes that are relevant to their area of interest.
  • Human druggable genome
    Qiagen has delivered its Human Druggable Genome siRNA Set V2.0 to the Scripps Research Institute in Florida. This second generation siRNA set from Qiagen enables efficient and effective gene silencing studies of 6992 potential human druggable targets. siRNAs are designed using the HiPerformance siRNA Design Algorithm, ensuring maximum silencing and minimum risk of non-specific effects.
  • DNA analysers for direct medical sequencing
    The Applied Biosystems TargetSeq Resequencing System is a software system for high-throughput directed or medical sequencing designed for use with Applied Biosystems 3730 and 3730x1 DNA Analysers.
  • Gene expression sample preparation
    Biomek 3000 GeXP Methods for automated gene expression sample preparation is a software plug-in that provides methods to prepare samples for the GenomeLab GeXP Genetic Analysis system on the Biomek 3000 Liquid Handling Workstation. The suite includes fully validated methods for RNA sample prep, quantitation and normalisation and reaction set-up. When used together, the Biomek 3000 workstation and these validated methods along with the GeXP Genetic Analysis system deliver a complete solution for gene expression analysis, from sample to answer.
News (40)
  • Qiagen expands partnership
    Qiagen has entered into an agreement with the Dutch molecular diagnostic component supplier Genome Diagnostics, which covers the development and commercialisation of six new tests until 2011.
  • Plagiarism and comparative genomics
    Feature frequency profiles similar to the system universities use to check if students have plagiarised their essays can be used to great effect in comparative genomics.
  • Australian gene technology launched in US
    A microarray that consists of both mRNA and non-coding RNA content which helps to elucidate the function of specific non-coding RNAs in relation to known pathways of gene expression has been invented at UQ and now marketed to the US.
  • Multiple genes for eye colour
    An Australian study has been the first to prove conclusively that there is no single gene for eye colour.
  • Genetic fingerprint unmasks microbial vandals
    For the first time DNA analysis can identify paper-degrading microorganisms. This is made possible by a molecular process developed for fungal infected documents at the University of Vienna with support from the Austrian Science Fund FWF.
  • Vaccine for East Coast fever
    Every year, East Coast fever destroys more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in the Proceedings of the National Academy of Sciences, shows how genomics can generate pivotal new vaccines.
  • DNA ends hold secrets to combating ageing and cancer
    An enzyme that is billions of years old holds the promise of renewing ageing tissues and combating cancer.
  • A gene for moonlight romance?
    A team of Australian and Israeli researchers has possibly discovered the aphrodisiac for the biggest moonlight sex event on the planet.
  • Web-based genomics computational resource facilitates research
    Researchers from Cincinnati Children's Hospital Medical Center and the University of Cincinnati (UC) Academic Health Center at the Computational Medicine Center have established a gene information resource designed to aid biomedical researchers in more effectively identifying small alterations in the human genome that are associated with individuals' susceptibility to disease.
  • Scientists uncover DNA repair mechanism
    Scientists at the American Johns Hopkins University have now uncovered the mechanism the body uses to identify and remove errors in the genetic code, according to the prestigious scientific journal Nature.
  • Genetics responsible for termite caste system
    Researchers have discovered that the termite caste system is influenced by genetic inheritance, a finding which could lead to new ways of combating the pest.
  • Could bacterial infections be altering our DNA?
    Scientists have discovered the genome of a bacterial parasite incorporated into the genome of its host species, according to a report published recently in Science.
  • Gene technology noble if used to save lives
    Research has shown the Australian public value gene technology more highly if it can save lives or significantly improve the quality of life.
  • Three is better than two but not than four
    Three-stage procedures offer an optimal relationship between costs and benefits in analysing genetic influences in diseases and therapies, a fact that has major practical importance for the ever growing number of gene analyses.
  • Viruses may be key to animal background
    The University of Auckland's Faculty of Science's Dr Alexei Drummond has been part of a global research team analysing the genetic sequences of viruses in animals.
  • Globetrotting rat genes reveal spread of human diseases
    DNA of the common Black Rat (Rattus rattus) has shed light on the history of the spread of rats, people and diseases around the globe.
  • Binocular vision gene sighted
    A team of international researchers have identified an important gene responsible for binocular vision.
  • Brain gene flicks the switch on gender
    University of Adelaide researchers have discovered a way of creating a male mouse without a Y chromosome by manipulating a single gene in the developing foetus.
  • Scientists find missing link in eye evolution
    A primitive fish that oozes reams of slime when it is unsettled could be the missing link in the evolutionary sequence of the vertebrate eye, according to a team led by a vision expert from The Australian National University.
  • Eureka for genetics and climate research
    Two of Australia’s top researchers received awards last night at the Australian Museum Eureka Prizes Award Dinner at the Australian Technology Park, Sydney.
  • Technique for identifying microorganisms
    Scientists at the US Department of Energy's Brookhaven National Laboratory have developed a high-throughput technique for identifying the many species of microorganisms living in an unknown 'microbial community'.
  • Evolutionary study finds 300 hidden genes
    Researchers at Cornell have discovered some 300 previously unidentified human genes and found extensions of several hundred genes already known, according to a study published online in the journal Genome Research.
  • Viral invasion of the koala genome
    University of Queensland researchers may have discovered why the koala is susceptible to certain infections and cancers.
  • Genomic test to predict who needs chemotherapy
    Duke University Medical Center scientists have developed a genomic test to predict which patients with early-stage lung cancer will need chemotherapy to live and which patients can avoid the toxic regimen of drugs.
  • Eucalyptus tapped as the next tree genome to be sequenced
    An ambitious international effort has been launched to decode the genome of Eucalyptus, one of the world's most valuable fibre- and paper-producing trees - with the goal to maximise its potential in the burgeoning bio energy market and for capturing excess atmospheric carbon.
  • Gene patent study misleading
    A report in Science journal relating to gene patenting claimed: "Nearly a fifth of all human genes have been patented, a study has found, leading to fears that research into diseases such as breast cancer, diabetes and obesity could be stifled."
  • Neanderthal genome sequencing yields surprising results
    Scientists with the US Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the Joint Genome Institute (JGI) have sequenced genomic DNA from fossilised Neanderthal bones with surprising results.
  • How the circadian rhythm affects gene regulation
    In recent years, scientists have discovered that biological clocks help organise a dizzying array of biochemical processes in the body — but exactly how the microscopic pacemakers in every cell in the body exert such a widespread influence has remained a mystery.
  • Genomic technology provides footrot breakthrough
    Footrot in sheep may become a disease of the past thanks to research developed collaboratively between scientists at Monash University and The Institute for Genomic Research (TIGR) in Maryland, USA.
  • Collaboration to accelerate biomedical discovery using siRNA library
    An alliance between Dharmacon and 14 international research centres have announced their progress towards their fundamental goal of developing internationally accepted standards for conducting research using the first complete siRNA library.
  • New hope for disease prediction
    For the first time, scientists can now show how a particular family of diseases is passed down from mother to child, and how this can lead to the severity of the disease differing widely.
  • Sequencing the Eucalyptus
    The US Department of Energy Joint Genome Institute (DOE JGI) has announced its latest community sequencing programs.
  • New gene shows way for autoimmune disease
    A new gene suspected to contribute to autoimmune diseases such as type 1 diabetes and lupus has been discovered by ANU immunologists.
  • What sequencing the first marsupial genome means for human health
    Sydney University researchers have helped to produce the first genome sequence for a marsupial, as part of an international collaboration studying the development of the mammalian immune system.
  • Aussies’ role in marsupial sequence
    The groundbreaking first DNA sequence of a marsupial, announced earlier this week in the science journal Nature, included research by 11 Australians among its 63 international authors.
  • New genes linked to diabetes and triglycerides
    Scientists from the Broad Institute of Harvard and MIT, Lund University and Novartis have discovered three unsuspected regions of human DNA that contain clear genetic risk factors for type 2 diabetes and another that is associated with elevated blood triglycerides.
  • Fruitfly genome reveals shortcomings of modern genome analysis
    Hundreds of scientists from more than 100 institutions in 16 countries have combined to sequence and compare 12 fruit fly genomes, in an effort that has increased researchers ’ understanding of fruit flies but, more importantly, also revealed considerable flaws in the way scientists identify genes.
  • Research finds cancer drug susceptibility gene
    Researchers have identified a cancer-prevention gene that influences the success of drug treatment for childhood cancer.
  • Arthritis genes identified
    A Queensland scientist has discovered two genes responsible for developing a form of arthritis known as ankylosing spondylitis, according to research published in the latest edition of
  • Scientists find genetic key to autoimmune diseases
    The discovery of how the gene Roquin suppresses autoimmune diseases like Type 1 diabetes and lupus could open the way for improved treatments for such conditions, scientists propose.
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