ORF Genetics ISOkine human recombinant leukaemia inhibitory factor (LIF)

Monday, 07 June, 2021 | Supplied by: Sapphire Bioscience


Leukaemia inhibitory factor (LIF) is a pleiotropic lymphoid factor belonging to the interleukin-6 family of cytokines. It was initially described as a factor inhibiting the proliferation of myeloid leukaemia cells and inducing their differentiation into macrophages. Other activities of LIF include inhibition of adipogenesis and roles in cholinergic neuron differentiation, haematopoiesis, inflammation and bone metabolism. LIF inhibits the differentiation of embryonic stem (ES) cells and is therefore important in ES cell culture. Human and mouse LIF share 78% amino acid homology; the human version is equally active on human and mouse cells but murine LIF is not active on human cells.

ORF Genetics’ ISOkine human recombinant LIF is a highly purified and endotoxin-free cytokine produced in the endosperm tissue of barley grain (Hordeum vulgare). The company says ISOkine biological activity is typically comparable to or better than other commercially available growth factors and cytokines, reflecting the eukaryotic folding and glycosylation pattern of proteins produced in plant cells.

Online: www.sapphirebioscience.com
Phone: 02 9698 2022
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