The Phenomenex Onyx C18 Semi-Prep 100 x 10 mm is the latest addition to the portfolio of monolithic silica HPLC columns. This format allows for flow rates from 5 to 35 mL/min with loading capacities typically between 10 and 20 mg. Onyx Semi-Prep is suitable for high-throughput purifications where impure samples and abusive ballistic gradients are encountered, such as in combinatorial library purifications. Also, due to the physics of the monolith, the DMSO solvent slug is well mixed, improving purification results. In addition to high-throughput purification advantages Onyx has very low backpressures and good flow characteristics, which allows for injection of very dirty and/or viscous sample.
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