Azure Biosystems Sapphire FL+ large-format biomolecular imager

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From large-format phosphor screens to high-throughput imaging workflows, the Sapphire FL+ by Azure Biosystems offers a 46 x 25 cm scanning bed — a scan area spacious enough to accommodate even oversized samples. From western blots to 2D gels, microscope slides, model organism imaging, multi-well plates, tissue arrays and protein arrays, the product is designed to provide high flexibility and precise quantitation of molecular assays.

The Sapphire FL+ has been billed as one of only two scanners in its class that supports phosphor imaging — a highly sensitive assay that utilises radioactivity. It can scan storage phosphor screens up to 20 x 40 cm, delivering 24-bit dynamic range and high image quality through its use of laser excitation and photon multiplier tube (PMT) detection.

The Sapphire FL+ features a novel, patent-pending design of interchangeable and customisable laser and filter modules, enabling a virtually infinite number of spectral combinations. A broad range of excitation and emission wavelengths, as well as phosphor imaging, are supported.

The instrument offers laser options from UV to NIR wavelengths (375–900 nm), 5–1000 μm resolution scans and a Z-plane range from -1 to +6 mm. Whether imaging western blots, gels, 96-well plates or tissue slides, the adjustable Z-plane provides optimal focus for every sample.

An optional Chemiluminescence Module adds high-resolution, quantitative chemiluminescence and visible imaging. It allows users to capture proteins with femtogram sensitivity and provides the ability to capture colour marker images.