GE Healthcare Life Sciences Biacore 8K surface plasmon resonance (SPR) system

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Biacore 8K is an eight-needle, high-sensitivity surface plasmon resonance (SPR) system from GE Healthcare’s Life Sciences business. It offers high-quality kinetics and affinity data at a speed that is said to shorten time to results by up to eight times compared to single-needle systems.

Its flexibility facilitates the analysis of small fragments through to multidomain proteins as well as drug formats such as bispecific antibodies. Its sensitivity and stability generate high-quality binding data for small molecules binding to complex targets such as GPCRs, and provides an alternative to traditional immunoassays such as ELISAs.

Eight needles allow the analysis of up to 2300 small-molecule fragments in a day and the novel 2D kinetics methodology delivers full kinetic characterisation data within 35 min, without the need for extensive assay development. Affinity and kinetic ranking enables rapid selection of biotherapeutic or small-molecule hits, while detailed kinetic and affinity data help to characterise and optimise selected binders.

Additionally, the system can generate high-quality kinetic characterisation of 64 interactions in 5 h and the ability to analyse samples in crude matrices, reducing the need for sample preparation. Coupled with intuitive software, the product provides quick interaction analysis for users at all levels of experience.

For more information: http://www.gelifesciences.com/biacore8K.