Malvern Panalytical MicroCal PEAQ-ITC isothermal titration calorimeter for measuring binding affinity and stoichiometry

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Understanding binding affinity is central to interpreting the intermolecular interactions that drive biological processes, structural biology and structure–function relationships. It is also central to drug discovery, where accurate measurement of binding strength and specificity underpins the design of effective, targeted therapeutics.

The MicroCal PEAQ-ITC from Malvern Panalytical is engineered to be an essential tool for biological interaction analysis, delivering precise measurements of affinity and stoichiometry in a single, label-free experiment.

While many isothermal titration calorimetry (ITC) systems provide basic thermodynamic data, they often are limited by sensitivity, complex workflows and data uncertainty. The PEAQ-ITC is designed to overcome these limitations through a combination of advanced hardware and intelligent software. Unmatched signal stability and lower noise compared to other systems are designed to enable accurate analysis of weak or complex interactions, even at low concentrations. Its enhanced sensitivity is designed to enable detection of interactions (eg, protein–protein, protein–small molecule and protein–nucleic acid) that many other systems simply cannot resolve.

Critically, common sources of error — such as inactive protein fractions or inaccurate ligand concentrations — can significantly distort binding data. PEAQ-ITC’s advanced analysis software is engineered to identify and correct these issues, allowing researchers to recover reliable thermodynamic parameters and improve confidence in structure–activity relationship (SAR) studies.

Ease of use is another defining feature. With PEAQ-Expert guidance tools, automated data quality assessment and rapid experiment-to-result workflows, users can generate high-quality data in under 30 minutes with low sample consumption and fully automated operation. By combining superior sensitivity and streamlined workflows, the MicroCal PEAQ-ITC is designed to deliver more accurate, reproducible data.

For more information: https://www.atascientific.com.au/products/malvern-microcal-peaq-itc/.