Malvern Panalytical NanoSight Pro for precision in drug delivery nanoparticle analysis

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As nanoparticle-based drug delivery advances modern therapeutics, accurate characterisation has never been more critical. From liposomes to polymer nanoparticles, size and concentration directly influence targeting efficiency, circulation time and therapeutic performance. The Malvern Panalytical NanoSight Pro is engineered to address this challenge with an advanced nanoparticle tracking analysis (NTA) platform. NanoSight Pro is a widely adopted NTA solution in biomaterials research designed to deliver rapid and robust, highly repeatable results.

The NanoSight Pro visualises and tracks individual particles in real time, measuring size distribution — typically ranging from 10 to 1000 nm — and concentration simultaneously. This particle-by-particle approach is designed to enable users to quickly assess critical quality attributes with minimal sample preparation, making it suitable for complex drug delivery systems.

A key advantage is its ability to combine light scatter and fluorescence detection. This allows users to distinguish between nanoparticle populations — such as empty versus cargo-loaded liposomes — even when sizes are similar. This capability is vital for formulation optimisation and controlled delivery.

NanoSight Pro is designed to overcome common limitations of traditional NTA systems. Automated workflows are designed to reduce user bias and improve reproducibility, while intelligent analysis algorithms are designed to reduce variability and ensure consistent results. In addition, flow-based measurements are designed to overcome issues of low particle statistics and sampling bias seen in static systems, improving data robustness. Enhanced optics and detection sensitivity are designed to also minimise background noise and improve accuracy when analysing polydisperse or low-concentration samples.

With intuitive NS Xplorer software and real-time visualisation, the platform aims to ensure researchers can confidently analyse each particle as it is measured.

To learn more, or book a personal NanoSight Pro demo, visit https://www.atascientific.com.au/products/malvern-nanosight-pro/.