Malvern Viscotek SEC MALS 20

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The Viscotek SEC MALS 20 is an advanced multi-angle light scattering (MALS) detector for size-exclusion chromatography (SEC/GPC). It is used to measure absolute molecular weight of proteins, synthetic and natural polymers. In conjunction with a concentration detector, molecular size (expressed as the radius of gyration) can also be determined.

For proteins, the product measures the absolute molecular weight independent of column retention volume in order to study oligomeric state and aggregation. In combination with two concentration detectors, it can also measure the molecular weight of conjugates such as PEGylated and detergent-soluble proteins. For natural and synthetic polymers, MALS provides molecular weight and Rg. It also offers insights into molecular structure through conformation plots of Rg with molecular weight.

The product marks the end of tedious column calibration, as MW is independent of elution volume. The device features improved angular coverage, plus multiple low-angle (low-noise) detectors to improve accuracy. The unit’s vertical flow cell with radial optics minimises noise. The product has a small footprint and only one cell is needed for all solvents.

Malvern’s static light-scattering detectors, including low-angle (LALS), right-angle (RALS) and multi-angle (MALS), are available individually and are compatible with any commercial GPC/SEC system, or may be supplied integrated within a multi-detection Viscotek system for comprehensive polymer, protein and macromolecule characterisation.