MBF Bioscience SLICE Light-Sheet Microscope

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MBF Bioscience’s SLICE Light-Sheet Microscope is engineered to expand access to high-performance 3D imaging by combining research-grade capability with a compact, cost-effective benchtop format. SLICE supports a broad range of applications across neuroscience, cancer research, developmental biology, tissue engineering, core imaging facilities, and translational research in biotechnology and pharmaceutical environments.

SLICE is designed to deliver performance comparable to substantially more expensive systems, with approximately 1 µm lateral resolution and 5 µm axial resolution for imaging cells and fine neuronal processes throughout cleared tissue. The platform also offers three-wavelength imaging capability for flexible multi-channel imaging applications.

Designed to meet the practical needs of modern neuroscience and biology laboratories, SLICE reduces the infrastructure demands often associated with advanced light-sheet imaging. Originating from the Tomer Lab at Columbia University and based on Projected Light Sheet Microscopy (Chen et al., 2024), the system received the 2025 Microscopy Today Innovation Award and is now installed at more than 30 leading research institutions across three continents.

The system supports imaging of whole mouse brains, cleared organs and organoids at sub-micron resolution, while accommodating major clearing workflows, including iDISCO, CLARITY, CUBIC and BINAREE, without requiring hardware changes. Its benchtop footprint eliminates the need for a vibration isolation table, while BrightSLICE software provides an integrated environment for image acquisition, processing and visualisation without requiring separate licensing or third-party software assembly.

Together, these features are designed to position SLICE as a practical, research-ready platform for laboratories seeking high-quality 3D imaging in a compact and accessible format.