Wednesday, 28 March, 2012 | Supplied by: AB Sciex Australia Pty Ltd

The AB SCIEX QTRAP 4500 system re-engineers the 4000 QTRAP platform to improve quantitation and library searching. It is suitable for use in research focused on ADME, regulated bioanalysis, food and environmental contaminant screening, targeted quantitative proteomics or forensic toxicology.

A Triple Quads with optional Linear Accelerator trap technology, the system enables: qualitative analysis with sensitive ion trap; simultaneous quantitation and library searching using TripleTrap scanning; MRM3 quantitation workflow for enhanced selectivity in complex matrices; simultaneous quantitative and qualitative analysis.

Its QTRAP technology is said to provide a 100x increase in full scan sensitivity over basic triple quads. Benefits include: simultaneously quantitate MRMs and perform full scan library searches for non-targeted contaminants; increased full scan sensitivity, beneficial for forensic toxicology applications; increase selectivity with quantitative MRM3 workflows and reduce the need for extensive sample clean-up; obtain comprehensive peptide sequence confirmation and simplify MRM assay development for peptide quantitation.

The series uses eQTM electronics providing polarity switching speeds of 50 ms and scan speeds of 20,000 Da/s, beneficial for detecting unexpected contaminants. Combined with a single comprehensive library of thousands of QTRAP spectra for library matching, contaminants at the lowest levels can be identified on a UHPLC time scale.

MRM3 workflows provide enhanced quantitative selectivity when high background or challenging co-eluting interferences make standard MRM quantitation difficult. This type of higher selectivity workflow can facilitate the quantitation of tryptic peptides in complex matrices and help avoid the need for labour-intensive chromatography methods.

The Turbo V source provides high-sensitivity analysis over a wide range of flow rates with quick-change APCI and TurboIonSpray probes. With functional flow rate ranges from 5 µL/min to 3 mL/min, the Turbo V Source is suitable for narrow bore, standard bore, micro flow and analytical flow UHPLC flow rates, delivering good desolvation and stability for demanding applications.

The QJet 2 Ion Guide design yields improved ion containment and operates at higher pressures providing better collisional focusing to enhance ion transmission and increase sensitivity. Its design also reduces the gas load, allowing the turbo pump to run cooler in its ideal operating range. With tool-free maintenance, routine clean-up of the QJet 2 can be accomplished within minutes.

The Convert Methods Utility is a tool that tales pre-developed Analyts MS-methods established on the 3200, 4000, 5000 and even 5500 platforms and updates them instantly for use with the 4500 Series for accelerated integration.

It is suitable for research use only, the series is not for use in diagnostic procedures.

Online: www.sciex.com
Phone: 1300 62 7777
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