Shimadzu Nexera MP Ultra High Performance Liquid Chromatograph

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The Nexera MP Ultra High Performance Liquid Chromatograph is available as a front-end system for LC/MS. The Nexera MP is suitable for LC/MS analysis conducted in pharmacokinetics and synthesis stages in drug discovery processes.

The Nexera MP uses the SIL-30ACMP Multiplate Autosampler, which provides good injection repeatability in micro volume injections (1% max in 0.5 µL injections, 0.5% max in 1 µL injections and 0.2 % in 5 µL or higher volume injections). The influence of sample solvents, which causes problems in analysis of deproteinised or synthetic samples, can be minimised by reducing the injection volume. Therefore, samples can be directly injected without dilution to streamline the sample preparation process.

By combining the Nexera MP with Shimadzu’s LCMS-8030 Ultra High Performance Triple Quadrupole Mass Spectrometer or the LCMS-2020 Ultra High Performance Single Quadrupole Mass Spectrometer, a system for analysing multiple samples quickly at a high accuracy can be created.

In the pharmacokinetics and candidate compound synthesis stages in drug discovery processes, multiple samples need to be analysed in a short time using an LC/MS system to attain higher throughput. In addition, in these processes, minimisation of carryover in samples is now more important than ever in order to enhance the reliability of LC/MS analysis as mass spectrometers are becoming more and more sensitive.

If using the Nexera MP, each person can set a sample plate without delay, even during analysis. Therefore, analyses previously run in multiple systems can be run on one system, saving energy and operation costs.

The Nexera MP can be controlled from Shimadzu’s LabSolutions software and major LC/MS workstations made by other companies.