Biotage Isolera Dalton mass directed flash purification system

Biotage has launched the Isolera Dalton - a fully automated miniaturised mass directed flash purification system. The system integrates a miniaturised mass detector and a flash chromatography system into one platform.

The mass detector and Isolera Spektra flash purification system are seamlessly integrated via the Isolera Dalton Nanolink unit, an intelligent sampling device which handles all fluids and synching calculations between the two units. Isolera Dalton easily fits inside a standard fume hood, requires no external pumps and is capable of both normal and reverse-phase separations, so it is compatible with the diverse purification needs of the modern research laboratory.

Compounds are identified in real time during purification and this informs the flash fractionation process, enabling the correct product to be collected by the system. The system automatically accommodates different column sizes and flow rates, overcoming issues with simple splitter-based systems. The product reduces the number of steps required to purify and confirm a target compound, thus improving workflow and increasing confidence that chemists have synthesised what was intended.

The instrument uses a wizard-based approach to method development. Simple on-screen prompts guide chemists through the system, even those whose expertise lie in compound synthesis rather than analysis.