Pall 5 mL prepacked PRC columns

Pall Corporation has launched 5 mL PRC prepacked chromatography columns to deliver faster and more consistent protein purification processing. The PRC prepacked columns for ion exchange and mixed-mode chromatography lower processing costs and save laboratory time by reducing inconsistencies associated with manually packed columns.

PRC columns are available in a wide range of separation media to support applications including native and recombinant proteins, plasmids, vaccines, monoclonal and polyclonal antibodies, and plasma derivatives.

The ready-to-use columns provide a direct connect to existing lab-scale chromatography systems. The columns are efficient (greater than or equal to 2500 plates/m) and their performance remains consistent throughout a process.

Pall 5 mL PRC columns are available prepacked with Q and S HyperCel ion exchange chemistries which feature very good flow properties and high dynamic binding capacity at short residence time. The columns also support the selectivities of Pall’s MEP, HEA and PPA HyperCel mixed-mode sorbents.

The 5 mL PRC columns are the latest additions to a line that includes 1 mL prepacked columns. These development-scale columns provide rapid selectivity screening of the desired chemistry. Simple optimisation can be achieved by coupling two columns in series to replicate production-process typical bed heights. Additional scale-up can be achieved with minimal re-optimisation by packing Pall LRC empty glass columns.