Sartorius BioPAT Spectro Raman spectroscopy tool

Thursday, 27 February, 2020 | Supplied by: Sartorius Australia Pty Ltd

Sartorius has introduced BioPAT Spectro, a Quality by Design (QbD) tool for use with ambr automated micro and mini bioreactor systems and BIOSTAT STR single-use production bioreactors. The tool offers access to Raman spectroscopy analysis in high-throughput process development, supporting fast Raman model building and accelerating scale-up into commercial manufacturing.

Raman spectroscopy is non-invasive and can measure multiple analytes, making it suitable for process control and monitoring of cell cultures. But offline approaches to obtain and consolidate enough data to produce a robust Raman model can be time‐consuming. BioPAT Spectro can be retrofitted into ambr 15 cell culture and ambr 250 high-throughput systems, and enables quick and simple sampling for integrated at-line analysis of a large number of analytes by Raman spectroscopy in a Design of Experiments (DoE) approach.

Consisting of a multi-use flow cell integrated into the ambr analysis module, the product is compatible with Raman spectrometers from Kaiser Optical Systems and Tornado Spectral Systems. The online Raman spectroscopy data, alongside data from the ambr process and selected integrated analysers, is automatically collated by the ambr software and can be easily transferred to SIMCA Multivariate Data Analysis (MVDA) software to build robust Raman models.

All integrated sampling, sample analysis, data collection and consolidation is automated, enabling walkaway Raman spectroscopy analysis in high-throughput process development. Additionally, one ambr run in 24 mini bioreactors can cover a wide design space, rapidly providing all the data required to build robust Raman models to support QbD in less than half the time of the conventional benchtop approach.

Developed with scalability in mind, BioPAT Spectro’s flow cell’s Raman probe interface and optical path design is identical across scales so it enables time-saving, automated in-line Raman spectroscopy with the company’s single-use bioreactors.

Phone: 03 8762 1800
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