Thermo Scientific Exactive Plus LC-MS with EMR option

With the extended mass range (EMR) option for the Thermo Scientific Exactive Plus LC-MS, proteomics scientists have a tool for challenging high-resolution accurate mass (HRAM) intact protein analysis such as investigating the structure, topology and architecture of targets. These include impurities in monoclonal antibodies, antibody-drug conjugates, PEGylated proteins, oligomerised protein-based drugs, glycoforms and protein assemblies.

The EMR option includes an extended m/z range of 350-20,000; improved transmission of higher-mass ions for stronger signals; modified HCD pressure and controls for easier optimisation of experimental conditions; and access to long transients for improved signal-to-noise ratio.

The product allows scientists to characterise native protein complexes with high sensitivity and mass resolving power. It will be a suitable tool for deciphering molecular mechanisms of protein machine assembling and protein complex/drug interactions.