Thermo Scientific Orbitrap IQ-X Tribrid mass spectrometer

Small-molecule researchers in academia, pharmaceutical and biopharmaceutical industries can now use an intelligent mass spectrometer (MS) to reveal complex chemical structures with ease and experimental versatility.

The Thermo Scientific Orbitrap IQ-X Tribrid mass spectrometer has been designed specifically for small-molecule structural elucidation of metabolites and unknown compounds. The wide range of applications includes metabolomics and lipidomics research, leachable/extractable impurities identification and forensic toxicology. The MS system provides a fit-for-purpose, AcquireX workflow enabled by Thermo Scientific Tribrid architecture to acquire high-quality data. Performance is enhanced by a Met-IQ workflow that leverages real-time library search with on-the-fly intelligent MS² spectral matching for decision-based triggering of MSⁿ scan events, providing confidence for chemical annotation.

Traditionally, ultrahigh-resolution and accurate mass calibration has been challenging and time-consuming. The MS system offers researchers high sample throughput with ease of use. Along with the intelligence-based data acquisition, the product also uses the Auto-Ready ion source for automated, remote and walkaway calibration, enabling the researcher to spend more time obtaining results and less time on instrument set-up.

The MS system provides improved fragmentation for small-molecule analysis with options to add to the platform’s experimental flexibility. An ultraviolet photodissociation (UVPD) option provides insights on the lipid double-bond localisation, site-specific glucuronidation and complementary fragmentation for structure assignment, while the 1,000,000 (1M) resolution option improves confidence for unknown analysis and fine isotope detection.