Thermo Scientific Q Exactive HF LC-MS system

The Thermo Scientific Q Exactive HF instrument is the latest in a range of liquid chromatography-mass spectrometry (LC-MS) systems. To create the system, the company added an ultrahigh-field Orbitrap mass analyser to the Q Exactive Plus LC-MS platform.

The product is designed for fast identification, characterisation, quantification and confirmation in a single analysis. Maximum scanning rate increases from 12 to 18 Hz accelerate productivity. The unit can provide complete MS/MS identification for 18 scans in one second, compared to half that number using the previous Q Exactive systems for the same duration gradient, without compromising data quality. Maximum resolution is 240,000 at m/z 200.

Advanced quadrupole technology optimises precursor selection and transmission for good detection of low-abundance ions in complex matrices. Active ion beam guide design enhances sensitivity and robustness. Quantitation capabilities include selected ion monitoring, parallel reaction monitoring and data-independent acquisition. An optional intact protein mode enhances analysis of intact proteins.