Thermo Scientific Q Exactive Plus LC-MS

Thermo Fisher Scientific is introducing the second generation of its benchtop hybrid HRAM instrument, the Thermo Scientific Q Exactive Plus LC-MS, to increase performance for applications such as bottom-up proteomics, lipidomics and high-confidence DMPK qual/quan screening studies.

The product’s Advanced Quadrupole Technology (AQT) was developed to improve precursor selection and transmission for accurate quantitation of low-abundance analytes in complex matrices. Its data-independent acquisition (DIA) and parallel reaction monitoring (PRM) are designed to deliver reproducible, high-throughput quantitation with high confidence in qualitative results. The advanced active beam guide (AABG) is designed to reduce noise and extend maintenance intervals.

The optional protein mode is designed to permit greater control over collision pressure and related parameters to improve analysis of intact proteins and protein complexes. The enhanced resolution option is intended to increase ID confidence in top-down proteomics and lipidomics studies.