Thermo Scientific Tundra Cryo-TEM

Cryo-electron microscopy (cryo-EM) is speeding the path to disease understanding and treatment; however, many institutions find these instruments to be out of reach because they are too complex for some researchers. The Thermo Scientific Tundra Cryo-TEM uses artificial intelligence (AI), guided automation and loader technology to simplify use, extending cryo-EM to researchers of any experience level.

AI and guided automation help non-experts quickly identify the quality of their samples and easily navigate an otherwise complex workflow. As the sample moves through the cryo-EM process, the results are displayed in a ‘traffic light’ style that helps scientists quickly determine if their sample is viable.

The integrated cryo-loading station replaces previous manual manipulation, enabling quick, effortless and robust sample loading and transfer to the microscope for immediate assessment and structure determination. Scientists can exchange sample carriers in about 2 min; this allows researchers to rapidly optimise biochemistry sample conditions as results can be checked immediately.

The product makes it possible for institutions and pharmaceutical companies to obtain structural insights at biologically relevant resolutions as high as 3.5 Å, with throughput within 24–72 h. It also delivers a compact footprint that fits most of today’s standard-sized labs, eliminating the need for potential renovations.