GENALICE Population Calling analysis module for large-scale DNA variation studies

GENALICE has announced the global launch of Population Calling, an analysis module and part of the GENALICE MAP Next-Generation Sequencing (NGS) Data Analysis Suite. The product is said to improve individual patient results and discover disease-specific DNA changes at a reduced time to result.

Single-sample variant detection is the standard approach to determine DNA changes in an individual patient that may be related to disease. Population Calling is an NGS data analysis methodology in which multiple samples from a cohort study are examined in a single-variant detection analysis. The aggregate information of all samples is used to improve the sensitivity and precision to detect all DNA changes in a single sample. This means that an individual patient’s diagnosis is enhanced using the consensus result of an entire cohort.

Population Calling is of high importance to large-scale DNA variation studies, but it also creates a big data challenge. As a result, the method has until now been the preserved territory of a select group of large institutes and companies that have extensive knowledge, resources, budget and patience to wait for results.

GENALICE says the Population Calling analysis module will make the method available to every single genomics researcher. The company claims the method will advance research and make medical breakthroughs through improved diagnosis and precision medicine, which tailors disease prevention and treatment to individuals driven by the analysis of their molecular profiles.