Proteintech Universal & Target Specific CAR Detection Reagents

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Chimeric antigen receptor (CAR) -based cell therapies are transforming treatments for cancer, autoimmune, and many other rare diseases. To support researchers developing and characterising CAR engineered cells, Proteintech offers a comprehensive range of CAR detection reagents designed for high sensitivity, lot-to-lot consistency, and compatibility with various workflows.

Proteintech’s reagents are designed to enable precise quantification and monitoring of CAR expression, ensuring robust and reproducible data in functional assays and clinical manufacturing settings. Each product is validated across multiple applications, offering flexibility for scientists working with diverse cell types and protocols. These reagents are designed to be well suited for verification, in-process analytics of the manufacturing process, and release testing of the manufactured clinical product.

Recombinant manufacturing is intended to ensure improved specificity, higher lot-to-lot consistency and reliable supply. The reagents are compatible in flow cytometry, immunofluorescence, and IHC-based applications for seamless integration into multiple workflows. FcZero technology is designed to abolish non-specific FcγR interactions and eliminate the need for additional blocking steps in flow cytometry.

Proteintech’s universal CAR detection reagents are designed to detect a broad range of CAR constructs through precise recognition of the scFv linker region. This is designed to minimise non-specific Fc receptor interactions, producing cleaner data, lower background and greater assay confidence. Incorporating AccuBright site-specific labelling technology, the reagent is designed to ensure uniform conjugation, enhanced brightness, and superior reproducibility across flow cytometry and related immunoassays.

The Target-Specific CAR Detection Reagent is purpose-built for flow cytometric detection and quantification of CAR-T cells. Featuring a native protein fused to a human IgG1 backbone, it is designed to enable direct, high-affinity binding to the target-binding region of CAR scFv, delivering clear and reproducible staining profiles that confirm both CAR expression and its interaction with the target.

For more information, contact United Bioresearch Products, distributor of the full range of Proteintech products in Australia: https://www.cosmobiousa.com/resources/product-insights/purefrex-protein-synthesis.