Enzo Life Sciences MegaCD40L enhanced TNF ligands

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The critical role of signals transmitted via TNF ligands and receptors in mediating inflammation, cancer and immunity has been well established. This understanding has been harnessed on the drug development frontier to mediate the pro-inflammatory properties of TNF signalling using ligand-neutralising antibodies (eg, Remicade) or soluble receptors (eg, Enbrel). Similar strategies have sought to use recombinant TNF ligands to enhance, for instance, antiviral and anticancer immune activation.

MegaCD40L from Enzo Life Sciences is an optimised soluble human CD40L oligomer, composed of two CD40L trimers joined via self-assembling chimeric domains. The oligomer has 10- to 100-fold lower endotoxin levels than comparable products.

The oligomer mimics in vivo membrane-assisted CD40L aggregation and stimulation without the need for enhancers. The product provides dependable lot-to-lot performance, and its optimised formulation improves stability and enhances activity.