Bio-Rad Laboratories anti-pertuzumab antibodies

Thursday, 03 February, 2022 | Supplied by: Bio-Rad Laboratories Pty Ltd


Bio-Rad Laboratories has introduced four inhibitory antibodies that are highly specific to pertuzumab (Perjeta). The ready-made antibodies inhibit the binding of the drug to its target, human epidermal growth factor 2 (HER2), enabling researchers to develop selective and sensitive assays for bioanalysis and drug monitoring of pertuzumab and its biosimilars.

Pertuzumab is a targeted cancer drug that binds to the HER2 protein, which is overexpressed in HER2-positive cancers, preventing cell growth and proliferation. The range of anti-pertuzumab antibodies includes monovalent Fab format antibodies suitable for the development of a pharmacokinetic bridging ELISA to measure free drug, as well as fully human IgG1 antibodies with varying levels of affinity, which can be used as a surrogate positive control or reference standard in an anti-drug antibody assay.

The antibodies are generated using the Human Combinatorial Antibody Libraries (HuCAL) and CysDisplay, a method of phage display, along with guided selection methods to obtain highly targeted reagents. The recombinant production method is designed to ensure a consistent and secure supply. The antibodies are approved for in vitro research purposes and for commercial services providing in vitro testing to support preclinical and clinical drug development.

Online: www.bio-rad.com
Phone: 02 9914 2800
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