Cerilliant Snap-N-Spike stable-labelled internal standards of antifungal agents

Cerilliant has introduced five stable-labelled internal standards of the antifungal agents fluconazole, itraconazole, ketoconazole, posaconazole and voriconazole at 1 mg/mL concentrations. The certified reference materials offer clinical and diagnostic testing labs, hospitals and bioanalytical/PKDM labs a full selection of internal standards for quantitation of the most common antifungal drugs in serum or plasma by mass spectrometry-based analytical methods.

The certified reference solutions are manufactured and certified to industry standards, including ISO Guide 34, ISO/IEC 17025 and ISO 13485, and are compliant with ISO 15194. The deuterium or ¹³C substitutions of each internal standard were carefully chosen to conserve a minimum [M+3] separation from the unlabelled drug in the major ion fragments used in LC-MS/MS antifungal TDM applications and metabolism studies.

The internal standards complement Cerilliant’s catalogue of triazole, imidazole and other azole antifungal certified spiking solutions. The company will also introduce stable-labelled internal standards for the antifungal metronidazole and active metabolite hydroxyitraconazole.