GeneTex SARS-CoV/SARS-CoV-2 (COVID-19) spike antibody [1A9]

SARS-CoV-2 has a ~29.9 kilobase positive-sense RNA genome that contains as many as 29 open reading frames. Though the exact number of functional proteins remains to be established, there are at least 16 nonstructural proteins (nsp), four structural proteins and at least six or seven accessory proteins. Based on previous work with SARS-CoV and other coronaviruses, scientists have identified functions for the majority of these factors, though work is ongoing.

The spike full-length (~1273 a.a. in SARS-CoV-2) protein precursor is cleaved into glycosylated subunits, S1 and S2. S1 binds to the host’s receptor, ACE2, while S2 mediates viral and host membrane fusion.

GeneTex’s SARS-CoV/SARS-CoV-2 (COVID-19) spike antibody [1A9], which detects both SARS-CoV spike and SARS-CoV-2 spike proteins (S2 subunit), has been validated for WB, ICC/IF, IHC-P, FACS, IP, ELISA, sandwich ELISA and IHC-P (cell pellets) applications.