IDT Alt-R Cas12a (Cpf1) Ultra CRISPR enzyme

Friday, 14 June, 2019 | Supplied by: Integrated DNA Technologies

Integrated DNA Technologies (IDT) has released its latest CRISPR enzyme, Alt-R Cas12a (Cpf1) Ultra. It is a powerful addition to IDT’s Alt-R CRISPR enzyme arsenal, with improved performance compared to previous products, making it easier to achieve precision genome editing at new sites across genomes.

Publication of the Cas12a system in 2015 generated interest among researchers seeking enzymes for genome editing experiments, particularly due to its PAM site (‘TTTV’) that expanded the number of potential editing sites in the genome beyond that of Cas9 (‘NGG’). IDT developed a novel mutant of the Acidaminococcus sp. BV3L6 Cas12a (Cpf1), called Cas12a Ultra. The mutant enzyme has enhanced editing activity, reaching or exceeding the performance of Cas9. It also retains activity across a wider temperature range than the wild type enzyme, making it useful for genome editing in additional organisms, including plants.

Alt-R Cas12a (Cpf1) Ultra is an addition to the genome editing toolbox that offers the same efficiency and versatility as Cas9. The tool will find equal utility for both knock-out and knock-in applications, in fields ranging from basic research cell engineering to medical gene therapy to agricultural biotechnology. By incorporating the enzyme into their research plan, scientists will also benefit from the good quality of IDT’s recombinant genome editing protein manufacturing, high-throughput guide RNA synthesis capacity and technical support.

Phone: 1300 489 122
Related Products

WPI Micro Fine Mesh Baskets

WPI has introduced a series of Micro Fine Mesh Baskets that are suitable for washing or...

AdipoGen animal-free recombinant monoclonal antibodies (RecMAbs)

AdipoGen develops recombinant monoclonal antibodies (RecMAbs) without the use of animals. The...

Larodan research-grade natural and synthetic phospholipids

Larodan develops a comprehensive range of research-grade lipids for use as analytical standards...

  • All content Copyright © 2019 Westwick-Farrow Pty Ltd