Lonza Potelligent CHOK1SV host cell line

Friday, 20 November, 2009 | Supplied by: Capsugel Australia Pty Ltd


Potelligent CHOK1SV, a host cell line for manufacturing recombinant antibodies, combines BioWa’s glycosylation Potelligent technology with Lonza’s GS Gene Expression System and CHOK1SV.

The cell line retains the features of a high-productivity cell line (robust, high-yielding, scalable) and the bioprocess platform for CHOK1SV is repeatable in the new cell line.

Antibodies produced by the new cell line: exhibit enhanced antibody dependent cellular cytotoxicity (ADCC) even with the low-ADCC allotype of CD16, overcoming CD16 polymorphism; can exert potent cytotoxic effects when their target antigen is low; work in whole blood; and retain required features of antibodies, such as Protein A binding.

Online: www.capsugel.com
Phone: 1300 657508
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