Lonza Potelligent CHOK1SV host cell line
Potelligent CHOK1SV, a host cell line for manufacturing recombinant antibodies, combines BioWa’s glycosylation Potelligent technology with Lonza’s GS Gene Expression System and CHOK1SV.
The cell line retains the features of a high-productivity cell line (robust, high-yielding, scalable) and the bioprocess platform for CHOK1SV is repeatable in the new cell line.
Antibodies produced by the new cell line: exhibit enhanced antibody dependent cellular cytotoxicity (ADCC) even with the low-ADCC allotype of CD16, overcoming CD16 polymorphism; can exert potent cytotoxic effects when their target antigen is low; work in whole blood; and retain required features of antibodies, such as Protein A binding.
Phone: 03 9550 0883
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