Sigma-Aldrich has announced that its custom manufacturing and services business unit, SAFC, is launching the CHOZN Platform system, a CHO (Chinese hamster ovary) cell expression system that allows for faster, simpler selection and scale-up of high-producing clones for the production of recombinant protein drugs.
The platform consists of the cGMP-produced and tested CHOZN ZFN Modified GS-/- CHO cell line, an optimised set of cGMP-produced, chemically defined media and specially designed feeds to maximise production of r-proteins. The system has been designed and tested to perform from initial cell line engineering process and stable cell line selection, through large-scale growth and production, providing an off-the-shelf production solution for biopharmaceutical developers who do not currently have a cell line platform.
Used for the production of biopharmaceuticals, the CHOZN GS-/- cell line is claimed to be the first commercially available glutamine synthetase (GS) knockout CHO line proven to shorten bioproduction times in early development, enabling customers to enhance their speed to market and decrease costs.
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