SAFC CHOZN Zinc Finger Nuclease-modified Chinese Hamster Ovary cell lines

SAFC has released its first offering in a product line of Zinc Finger Nuclease (ZFN)-modified Chinese Hamster Ovary (CHO) cell lines.

Designed for use in the production of biopharmaceuticals, the CHOZN cell lines are expected to enable users to reach the market faster and more cost-effectively by reducing timelines commonly associated with early-stage biological drug development. The distinctive features of the cell lines should appeal to organisations looking to build a robust and comprehensive therapeutic protein and monoclonal antibody manufacturing platform.

The CHOZN cell lines have complete traceability and the cell line is robust with regulatory-friendly features.

As part of the first offering of its dynamic cell line series, SAFC is releasing the CHOZN DHFR-/- CHO line for use in the production and manufacture of biological drugs. The DHFR-/- CHO line was developed through CompoZr ZFN mediated gene editing of the dihydrofolate reductase (DHFR) locus in a robust, extensively characterised and fully documented CHO-K1 host. The CHOZN DHFR-/- CHO line allows process development scientists to use any common DHFR expression system for the selection and amplification in a fully traceable CHO-K1 background.