Sigma Life Science engineered mammalian cell lines

Sigma Life Science has released a range of engineered mammalian cell lines. The product range combines Sigma’s CompoZr zinc finger nuclease (ZFN) technology with the company’s experience in gene silencing to offer tools for drug discovery, compound screening and fundamental research applications.

The product range includes immortalised cell lines for a broad spectrum of applications, each precisely engineered to help scientists answer specific biological questions. By exploiting the genomic editing capabilities of ZFNs, Sigma’s scientists can rapidly manufacture stable cell lines with precise, well characterised genetic manipulations.

The program will use ZFNs to incorporate and develop cell lines with a variety of cellular markers expected to aid in compound screening studies and biochemical pathway analysis, as well as specific isogenic lines designed to advance colorectal and breast cancer research. In addition, Sigma offers a custom cell line engineering service, creating bespoke cell lines to match a researcher’s application.