Thermo Fisher Scientific Gibco CTS OpTmizer Pro Serum Free Media (SFM)

Thermo Fisher Scientific has developed a medium for the development and expansion of human T lymphocytes (T cells) for cell therapy developers using allogeneic workflows. The Gibco CTS OpTmizer Pro Serum Free Media (SFM) is a media solution that targets the metabolism of healthy donor cells, making it suitable for use in the production of allogeneic, off-the-shelf cell therapies.

In contrast to autologous cell therapies, which are produced using a patient’s own cells, allogeneic cell therapies are derived from healthy donor tissue, potentially enabling more scalable cell therapy manufacturing. The SFM enhances donor T cell proliferation, maintains central memory T cells further into expansion and delays effector differentiation of healthy donor T cells, resulting in fast production of central memory cells.

The product packaging is suitable for closed systems and is manufactured in conformity with current Good Manufacturing Practice (cGMP) standards. The serum-free media is ready to use and compatible with automated and long workflows, providing a consistent formulation designed to maintain cell quality and increase the efficacy of cell-based therapies.