Shimadzu total organic carbon analysis application note

Shimadzu has published an application note to illustrate the capabilities of its TOC-L total organic carbon analyser for cleaning validation in the pharmaceutical industry.

To ensure quality control and safety in manufacturing facilities within the pharmaceutical industry, it is important that cleaning validation be conducted following the cleaning of production-related equipment to ensure that the quantity of residual substances is within permissible limits.

Depending on the sampling method and measurement method used for this cleaning validation using a TOC analyser, the following three types of methods are available. (1) Rinse sampling - TOC measurement method; (2) Swab sampling - aqueous extraction - TOC measurement method; (3) Swab sampling - direct combustion carbon measurement method.

The application notes describe each of these methods, using the TOC-L total organic carbon analyser in the measurement of residual pharmaceutical products and their constituent substances.

The application note is available for download at: http://www2.shimadzu.com/applications/TOC/O41.pdf