Active Motif CUT&Tag-IT R-loop Assay Kit

Click2Contact

R-loops are three-stranded nucleic acid structures that are formed when a single-stranded RNA invades the DNA double helix to hybridise with a complementary DNA strand, leaving the non-template DNA strand unpaired. These structures form normally during transcription initiation, IgG class switching and mitochondrial DNA replication. R-loops play a role in chromatin dynamics and can also be used as biomarkers in some cancers.

The CUT&Tag-IT R-loop Assay Kit from Active Motif is optimised to profile R-loops genome-wide and has several advantages. It is designed to be faster and more efficient than DNA:RNA immunoprecipitation (DRIP) and chromatin immunoprecipitation (ChIP) methods, and is compatible with 200,000 to 500,000 fresh or cryopreserved cells. The kit comes with all reagents necessary, including an optimised protocol.

For further information, contact United Bioresearch Products, the distributor of the full Active Motif range in Australia, or visit https://www.activemotif.com/catalog/1376/cut-tag-r-loop-kit.