Biomedica Big Endothelin-1 ELISA

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Endothelin-1 (ET-1) is a potent vasoconstrictor secreted by vascular endothelial cells. Due to its high biologic activity, the half-life of ET-1 (1-21) in plasma is less than 1 min, which may preclude its use as a diagnostic marker, whereas clearance of the precursor peptide Big Endothelin-1 is much slower. As Big Endothelin-1 is produced at amounts equimolar to ET-1 and has higher plasma stability, it is more suitable for diagnostics and monitoring of heart failure. Hence, Big ET-1 has the same physiological role as ET-1 while being a more appropriate marker and has been implicated in the pathophysiology of numerous cardiovascular diseases.

The Big Endothelin-1 immunoassay from Biomedica is a 5.5 h, 96-well sandwich ELISA for the direct measurement and quantitative determination of Big Endothelin-1 in serum and plasma. The assay employs human serum-based standards to ensure the correct measurement of biological data, is fully validated according to FDA/ICH/EMA guidelines and is highly cited.

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