Malvern MicroCal VP-Capillary DSC differential scanning micro calorimeter

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MicroCal differential scanning micro calorimeters provide fast and accurate determination of the stability of proteins, nucleic acids, micellar complexes and other macromolecular systems. Differential scanning calorimetry (DSC) directly measures the enthalpy (ΔH) and transition midpoint (T_m) to predict shelf life, develop purification strategies, evaluate protein constructs and rank the affinities of ligands to a protein target in small molecule drug discovery programs.

The MicroCal VP-Capillary DSC system enables the study of folding and unfolding without labelling or the use of artificial probes, so molecules are studied in their native states. The high-throughput, high-sensitivity product requires low sample volumes and features software that streamlines workflow through simplified experiment set-up. Automated data analysis and improved data sorting help relieve analysis bottlenecks, reducing data analysis time for a typical experiment from days to hours.

The systems are in use in over 1000 labs worldwide, both for R&D and commercial applications, and have over 10,000 citations in reference databases.