Shimadzu Noviplex Card for plasma collection

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Shimadzu Scientific Instruments has partnered with Novilytic Labs to offer technology for the rapid generation of plasma from whole blood. Noviplex is a simple, powerful tool used to collect a volumetric sample of plasma (2.5 or 5 µL) from a non-volumetric application of whole blood in just minutes.

An unmeasured application of between 20 to 75 µL of whole blood from a finger-stick, mouse tail-bleed or other source is all that is required to collect a volumetric plasma sample. The product can be used as a single-step, solid-phase method for sample preparation and analyte extraction, eliminating the need for time-consuming techniques such as solid phase extraction, centrifugation and evaporation.

The device offers 99% removal of red blood cells (based on Hb levels in plasma); inter-card CV of ~1% in plasma collection volume at constant hematocrit (HCT); and inter-card CV of 2% collection volume variation with 20% to 71% HCT. Proteins are deposited as a monolayer upon drying and metabolites are present in the protein monolayer.

The tool provides rapid sample preparation for MS-based analysis while maintaining assay reproducibility and selectivity; and good reproducibility independent of hematocrit.