WPI MICRO-ePORE pinpoint cell penetrator

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The MICRO-ePORE pinpoint cell penetrator from WPI is a simple and versatile system that can be used for efficient microinjection of a diverse array of components and biomolecules into oocytes and pre-implantation stage mammalian embryos. Flutter Electro Technology (patent pending) assists in small, clean, precise membrane penetration without tearing or damaging the membrane.

The cell penetrator offers a solution for microinjection resulting in high viability. The instrument creates an oscillating electric field at a localised site on the membrane immediately beneath the site of injection. This creates small, reversible holes in the plasma membrane through which material is microinjected. The research determines the amplitude and frequency of the signal that best suits the application. The result is that the membrane does not tear and thus allows for superior viability of embryos, according to the company.

The MICRO-ePORE cell penetrator has been successfully tested in mouse and primate pre-implantation embryos, as well as gene silencing in zebrafish.