Beckman Coulter SPRIworks Fragment Library System III

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SPRIworks Fragment Library System III automates the preparation of libraries for the Life Technologies SOLiD Sequencer. With the introduction of this third system in a series, researchers can use the SPRIworks system to automate library preparation for the three major next-generation sequencing platforms.

Combining solid phase reversible immobilisation (SPRI) chemistry and Beckman Coulter automation, System III facilitates the construction of consistent, quality libraries. Automating the library construction process saves researchers valuable time. One to 10 samples can be completed within 3½ h, and the process provides several size-selection and nick translation options.

The already introduced SPRIworks Fragment Library Systems I and II automate library preparation for the Illumina genome analyser and the Roche GS FLX DNA sequencer. Like those products, System III uses a dedicated, colour-coded method card and cartridges. Thus, library construction for all three sequencing platforms can be conducted using one instrument and the appropriate method card and cartridges.

System III is a validated plug-and-play system: users simply insert the method card, samples and adapters; select run options; and press start.