Caliper Life Sciences LabChip XT automated nucleic acid fractionation

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Current next-generation sequencing (NGS) workflows have numerous manual processes that bottleneck throughput and contribute to process inefficiency. One of the most time-consuming tasks is gel-based size selection during the library-generation process. In addition to being labour intensive and not scalable, manual methods introduce run-to-run and operator-to-operator variability. Furthermore, the imprecision of this manual excision results in the size selection precision (width of the selected band) being typically no better than ±10% of the median fragment size (eg, 400 bp ± 40 bp).

The LabChip XT fractionation system addresses these issues and performs fast, automated nucleic acid fractionation accurately and reproducibly. The resulting sample is tightly sized and is delivered in a sequencing compatible buffer. The XT improves laboratory efficiency and provides sizing that is difficult to obtain using manual methods. Data is displayed digitally and non-fractionated sample can be recollected and used at another time.