Enzo Life Sciences calcineurin cellular activity assay kit

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Calcineurin (PP2B) is a eukaryotic Ca2+ and calmodulin-dependent serine/threonine protein phosphatase. It activates the NFAT transcription factor, stimulating the T-cell response through IL-2 expression. It is involved in immune cell signalling and is a target for inhibitors, such as everolimus, which are used in heart transplantation to prevent rejection.

Enzo Life Sciences provides a complete colorimetric assay kit for measuring cellular calcineurin phosphatase activity. It employs a convenient 96-well plate format with all reagents necessary for measuring calcineurin phosphatase activity in tissue/cellular extracts. Human recombinant calcineurin is included as a positive control.

The product is a safe and non-radioactive colorimetric kinase assay which uses RII phosphopeptide substrate, an efficient and selective peptide for calcineurin. The one-step detection method is suitable for high-throughput cellular analysis.

For more information: http://www.enzolifesciences.com/BML-AK816/calcineurin-cellular-activity-assay-kit/