GeneCopoeia Genome-CRISP CRISPR human single guide RNA (sgRNA) libraries

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GeneCopoeia offers Genome-CRISP CRISPR human single guide RNA (sgRNA) libraries which consist of sets of single guide RNAs (sgRNAs) cloned into lentiviral vectors for dual-use (transfection or transduction) delivery methods.

The libraries are offered for high-throughput knockout of human genes in specific or custom gene groups or pathways. Loss-of-function screening by gene knockout is a powerful tool for systematic genetic analysis in mammalian cells, facilitating gene discovery, genome-scale functional interrogation (eg, signal transduction pathways) and drug discovery (eg, target identification and drug mechanism studies).

The individually constructed, sequence-verified, pooled sgRNA libraries ensure high quality and good sgRNA representation for selected target gene families. They are available in pre-made or custom sets, with two or more sgRNAs per target gene. Flexible delivery formats include pooled sgRNA plasmids, bacteria stocks and lentiviral particles.