LifeSensors ubiquitin ligase and proteasome inhibitors
LifeSensors has added several small molecule ubiquitin ligase and proteasome inhibitors to its range.
Carfilzomib is the active ingredient in the new clinical proteasome inhibitor Kyprolis.
Epoxomicin/BU-4061T is one of the most potent and selective proteasome inhibitors.
Oprozomib/ONX0912 is a clinical-stage proteasome inhibitor that selectively inhibits the chymotrypsin-like activity of the 20S proteasome.
MLN2238 is a potent inhibitor of the chymotrypsin-like activity of the 20S proteasome.
RITA/NSC652287 blocks p53-hdm2 interaction and p53 ubiquitination.
SKPin C1 inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2.
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