Lonza 384 StellARray Alzheimer’s disease qPCR array

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The 384 StellARray qPCR array is designed to profile the expression pattern of genes that may increase susceptibility, contribute towards the progression or provide a neuroprotective role in Alzheimer’s disease.

It measures genes involved in amyloid peptide processing and degradation, formation of protein aggregates, neuroinflammation, apoptosis and neuronal survival. Many genes in this array are known to have altered expression in patients with Alzheimer’s disease.

Also included is an important subset of genes expressed in the blood that has been recently shown to classify and predict Alzheimer’s disease.

Primer pairs are designed to detect both RNA (as cDNA) and genomic DNA in separate assays, which enables analysis of both gene expression and genomic DNA copy-number variations (CNV) derived from the same primer pairs.

The assay is wet-lab validated and selected to yield single peak melt curves. Strict manufacturing QA/QC procedures are used to ensure consistency of performance.