Mito-ID Membrane Potential Cytotoxicity Kit

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Mitochondria play a central role in cellular metabolism, bioenergetics and apoptosis. Decreased mitochondrial function is known to be a major contributor to drug-associated toxicity in various organs. Evaluating the mitotoxic effects of a drug is vital in the early drug development process.

Enzo Life Sciences’ Mito-ID Membrane Potential Cytotoxicity Kit measures fluctuations in mitochondrial membrane potential (MMP) by utilising a cationic dual-emission dye. Cells exhibit a shift from orange to green fluorescence as mitochondrial function becomes increasingly compromised. The Mito-ID Membrane Potential dye is said to be 10 times more sensitive than JC-1, with good aqueous solubility, allowing detection of toxicity at lower doses.

The kit is suitable for time-course studies evaluating intact and compromised mitochondria. With no-wash and no-medium removal, it is compatible with high-throughput applications.