Wyatt Möbius protein charge and kD measurement
Wyatt Technology has released the Möbius, a product which simultaneously measures protein charge and diffusion interaction parameter (kD) to determine the colloidal stability of two formulations with different long-term stability behaviour. It uses massively parallel phase-analysis light scattering (MP-PALS) in conjunction with an autosampler to automate the measurement.
Both charge and kD are important parameters to indicate colloidal stability, since charge alone may not provide a complete picture: molecules can have a favourable net charge though be destabilised by localised factors such as charge asymmetry and hydrophobic residues. The product can combine the measurement of charge and kD of monoclonal antibodies in parallel. It is thus suitable for protein characterisation and provides a complete picture of factors affecting a protein’s stability.
Phone: 02 9684 4200
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