Wyatt Möbius protein charge and kD measurement

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Wyatt Technology has released the Möbius, a product which simultaneously measures protein charge and diffusion interaction parameter (k_D) to determine the colloidal stability of two formulations with different long-term stability behaviour. It uses massively parallel phase-analysis light scattering (MP-PALS) in conjunction with an autosampler to automate the measurement.

Both charge and k_D are important parameters to indicate colloidal stability, since charge alone may not provide a complete picture: molecules can have a favourable net charge though be destabilised by localised factors such as charge asymmetry and hydrophobic residues. The product can combine the measurement of charge and k_D of monoclonal antibodies in parallel. It is thus suitable for protein characterisation and provides a complete picture of factors affecting a protein’s stability.