ACEA Biosciences xCELLigence Real-Time Cell Analyzer (RTCA)

The xCELLigence Real-Time Cell Analyzer (RTCA) from ACEA Biosciences allows for label-free monitoring of cellular processes such as cell proliferation, morphology, cytotoxicity, adhesion, viability, invasion and migration. Using an electronic cell sensor array technology, the system provides precise, physiologically relevant, quantitative data recorded throughout the entire course of an experiment.

The ability of different immune cells to cause targeted cytolysis of cancer cells is an exciting area for immunotherapy research. Utilising the power of the xCELLigence RTCA systems, researchers are able to investigate the short- and long-term cytotoxic effects on target tumours using a wide range of immune cell types, including natural killer (NK) cells, T-cells, CAR-T cells and macrophages, as well as the effects of antibody-dependent cell cytotoxicity (ADCC) and bispecific T-Cell engagers (BiTE) antibodies. Real-time kinetic cellular profiles generated provides reproducible, publication-ready data from a single experiment.

The system also enables a wide range of applications, including: cell invasion and migration; compound- and cell-mediated cytotoxicity; cell adhesion and spreading; cell viability, proliferation and differentiation; receptor-mediated signalling (GPCRs, RTKs); virus-mediated cytopathogenicity; cardiotoxic compound effects; and continuous quality control of cells in culture.