AdipoGen’s Gasdermin D (mouse) ELISA Kit is a sandwich ELISA for quantitative determination of mouse Gasdermin D in cell culture supernatants and cell extracts.
Gasdermin D is a central mediator of pyroptotic cell death. It contains a functional N-terminal domain and an inhibitory C-terminal domain. Upon caspase-1/11 cleavage of the linker located between the two domains of Gasdermin D, the cleaved N-terminal fragment of GSDMD oligomerises and forms pores on the host cell membrane, leading to cell death called pyroptosis.
The ELISA is specific for the measurement of natural and recombinant mouse Gasdermin D (full-length and C-terminus cleaved fragment). It has a sensitivity of 14 pg/mL and does not cross-react with human Gasdermin D.
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